The Historic City Centre of Prague consists of Old Town, New Town, and Lesser Town, all contained within the area of Praha 1 of the city in the Czech Republic. This architectural landscape blends the eras of gothic, renaissance, and baroque buildings and serves as a cultural beacon of attraction for locals and tourists alike. The Historic Centre is identified as a reputable representative landmark of medieval urbanism and a UNESCO World Heritage Site.

The City Centre houses a variety of monuments, palaces, and churches, and one of the most prominent and largest castles in the world, the Hradcany Castle. Another well-known landmark is the St Vitus Cathedral, an active religious centre of gothic design completed in the 19th century. The Valdštejn Palace and Gothic Charles Bridge are two other noteworthy monuments with extensive historical significance.

Transportation within the Historic City Centre is restricted to electric powered trams and metros to better preserve the area. Public buses are not allowed in the historic district due to pollution concerns. Walking is the most common form of transit throughout the city centre.

The significance of historic Prague dates back to the medieval ages. Prague experienced a destructive fire in 1541 and exponential decline through the Thirty Years War, both incidents resulting in an age-respective reconstruction. In true Renaissance and Baroque style, the diverse medieval city centre was rebuilt into the economic and cultural mecca that persists today.